prognostic and predictive factors in breast cancer by immunohistochemical analysis pdf

Prognostic And Predictive Factors In Breast Cancer By Immunohistochemical Analysis Pdf

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Published: 15.12.2020

Table of Contents

Objective: The role of hormone receptors as a prognostic and therapeutic tool in breast cancer is widely accepted. The aim of this study was to the analysis of steroid receptor status in breast cancer with clinic pathological characteristics. Methods: In the present study, immunohistochemical assay of two hundred tumor block of patients of breast carcinoma was performed to know the hormone receptor status as well as histological examination. Results: samples were grouped to study hormonal status and their relation with clinic-pathological factors. The results in the present study documented the The negative expression of ER, PR receptors found higher No significant association of lymph node status and histological types was found with receptor expression.

This is an open access article distributed under the terms of Creative Commons Attribution License. Breast cancer is responsible for the highest mortality in women worldwide 1. Breast cancer affects women in both developed and developing countries. The incidence of the disease is higher in developed countries, while the risk of succumbing to the disease is higher in developing countries 2. The difference in incidence between countries is partially explained by variations in the use of hormone replacement therapy and reproductive patterns, such as age at first child, number of children, age at menarche, and nutritional factors 3.

Prognostic and predictive factors for breast cancer

Predictive factors of breast cancer evaluated by immunohistochemistry. Hormone receptor and Her2 protein overexpression evaluated by immunohistochemistry IHC is widely validated as a predictive factor in breast cancer. The quality of the IHC reaction is influenced by tissue fixation and processing. Over- and underfixation deeply affect IHC results. Antigen retrieval may improve IHC but it does not recover tissue from autolysis or overfixation. The choice of primary antibody for IHC as to its sensitivity and specificity in relation to therapeutic response represents an important stage.

Helda Helsingin yliopisto Helsingfors universitet University of Helsinki. Koko arkisto Nykyinen kokoelma. Tarkennettu haku. PlumX data. Lataa tiedosto Jaa.


Correspondence Address : Dr. Breast cancer is a heterogeneous disease and may present with different clinical and biological characteristics. At present, breast cancer is divided into molecular subgroups besides its histopathological classification.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Immunohistochemistry IHC has an important role in the assessment of prognostic and predictive factors in invasive breast cancer IBC today.

Most recent decisions for breast cancer patients are made on the basis of prognostic and predictive factors. Pathologists today, however, are evaluating estrogen and progesterone receptors almost exclusively by immunohistochemical means. Although many studies suggest that these tests might have equivalent or even superior abilities to predict patient outcome, there are important methodologic shortcomings to resolve before this technology achieves the clinical and technical validation necessary to justify its routine use.

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Prognostic factors can be useful for making decisions about which patients should receive adjuvant therapy, and predictive factors can be used to predict response or lack of response to a particular therapy. We review the standard factors that are available today for primary breast cancer, and we describe some of the new, potential prognostic and predictive factors that are currently under investigation. Download to read the full article text. Surg Gynecol Obstet —, Cancer —, Semin Surg Oncol —, Mittra I, MacRae KD: A meta-analysis of reported correlations between prognostic factors in breast cancer; Does axillary lymph node metastasis represent biology or chronology?

Int Arch Med Microbiol Know the tumor stage of breast cancer and identify the immunohistochemical markers are important in the evaluation of predictive and prognostic factors, in the differential diagnosis of breast lesions and in the determination of the possible origin of metastatic neoplasms, besides helping to define the type of treatment. Cross-sectional and quantitative study of patients diagnosed with breast cancer, submitted to treatment at the Ceara Cancer Institute ICC mastology service from to Describe the main clinical and epidemiological characteristics of breast cancer treated at Haroldo Juacaba Hospital - Ceara Cancer Institute ICC : Identify types of breast cancer; to evaluate the initial staging, correlating axillary status, local and systemic treatment; to analyze the immunohistochemical profile through receptors standardized by the pathology department of the Hospital, correlating them with the current molecular classification of breast cancer.

Беккер держался своей легенды: - Я из севильской полиции. Росио угрожающе приблизилась. - Я знаю всех полицейских в этом городе. Они мои лучшие клиенты. Беккер чувствовал, как ее глаза буквально впиваются в .

for breast cancer patients are made on the basis of prognostic and predictive evaluating other factors for clinical use by immunohistochemical techniques, is still controversial, and, like the assessment of hormone receptors, there are.

Prognostic and predictive factors in breast cancer by immunohistochemical analysis

Тем не менее риск велик: если нас обнаружат, это, в сущности, будет означать, что он своим алгоритмом нас напугал. Нам придется публично признать не только то, что мы имеем ТРАНСТЕКСТ, но и то, что Цифровая крепость неприступна. - Каким временем мы располагаем.

Ничего более абсурдного Сьюзан слышать еще не доводилось. Цифровая крепость - не поддающийся взлому код, он погубит агентство. - Если бы я сумел слегка модифицировать этот код, - продолжал Стратмор, - до его выхода в свет… - Он посмотрел на нее с хитрой улыбкой.

Recent perspectives of breast cancer prognosis and predictive factors (Review)

Чатрукьян ввалился в комнату. - Коммандер… сэр, я… извините за беспокойство, но монитор… я запустил антивирус и… - Фил, Фил, - нехарактерным для него ласковым тоном сказал Стратмор.  - Потише и помедленнее. Что случилось. По голосу Стратмора, мягкому и спокойному, никто никогда не догадался бы, что мир, в котором он жил, рушится у него на глазах.

Возбужденный, Беккер ускорил шаги в поисках телефона. По другой стороне улицы, оставаясь невидимым, шел человек в очках в тонкой металлической оправе. ГЛАВА 27 Тени в зале шифровалки начали удлиняться и терять четкость. Автоматическое освещение постепенно становилось ярче.

Когда ее глаза привыкли к темноте, Сьюзан разглядела, что единственным источником слабого света в шифровалке был открытый люк, из которого исходило заметное красноватое сияние ламп, находившихся в подсобном помещении далеко внизу. Она начала двигаться в направлении люка.


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