Camel Milk And Diabetes Pdf
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- Can Camel Milk Help Your Diabetes? What You Should Know
- EFFECT OF RAW CAMEL MILK IN TYPE 1 DIABETIC PATIENTS : 1 YEAR RANDOMISED STUDY
- Can Camel Milk Help Your Diabetes? What You Should Know
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Can Camel Milk Help Your Diabetes? What You Should Know
Hypoglycemic effect of camel milk supplementation in experimental rat model and significant reduction in doses of insulin in type 1 diabetic patients have been observed in our previous studies. This long-term study was undertaken to assess the efficacy, safety and acceptability of camel milk as an adjunct to insulin therapy in type 1 diabetics. In this 2-year randomized clinical, parallel design study, 24 type 1 diabetics were enrolled and divided into two groups.
Insulin requirement was titrated weekly by blood glucose estimation. Results were analyzed by using the regression technique.
In camel milk group, there was decrease in mean blood glucose Out of 12 subjects receiving camel milk, insulin requirement in 3 subjects reduced to zero. There was nonsignificant change in plasma insulin and anti-insulin antibodies in both the groups. It may be stated that camel milk is safe and efficacious in improving long-term glycemic control, with a significant reduction in the doses of insulin in type 1 diabetic patients.
Camel milk has emerged as a potent therapeutic alternative, which can help in reducing insulin doses. Primary treatment of type 1 diabetes mellitus is insulin replacement. Although conventional injectable insulin therapy meets this goal, it is associated with several therapeutic disadvantages, such as hyperinsulinemia, pain and inconvenience. Many attempts have been made to find alternative methods of insulin delivery through non-invasive routes Owens, ; Gordberg and Gomez-Orellana, ; Cefalu, Among the alternative routes available for insulin delivery, oral administration is the most preferable, as it offers significant advantages in terms of therapeutic efficacy and patient acceptability.
As orally delivered insulin undergoes a hepatic pass before entering the circulation, it has the potential to mimic the effects of pancreas-secreted insulin in terms of inhibition of hepatic gluconeogenesis Lewis et al. Camel milk is one such alternative, as one of its proteins has many characteristics similar to insulin Abu-Lehia et al.
Radioimmunoassay of camel milk has revealed that it contains high concentration of insulin, that is, There is significantly higher insulin Taking all these evidences in account, a long-term study was undertaken to study the efficacy of camel milk in improving the glycemic control, consistent reduction in the doses of insulin and long-term safety profile in type 1 diabetes patients, with the aim that such an investigation would help to establish a more rational use of camel milk to control blood sugar levels in these patients.
In total, 24 type 1 diabetic subjects were randomly selected from the outpatient diabetic clinic in the PBM Hospital, Bikaner, India. The patients were advised to follow a strict diet, that is, fiber rich and low-fat diet, with 3-km daily walk and taking insulin treatment for 1 month before randomization as well as during the course of study.
During this period, frequent monitoring of blood sugar was done to maintain euglycemia. Allocation to the intervention and control groups was matched regarding their age and male to female ratio.
Mean body mass index BMI for both the groups were also compared before the study and was found nonsignificantly different. Randomization was computer generated. Both the groups were also matched for duration of diabetes diagnosis and duration of insulin therapy.
Patients were provided camel milk daily in the morning at the research center. Information about their compliance to camel milk consumption, and diet by h recall method and exercise was taken regularly by dietician. Patients with any acute metabolic complications like hypoglycemia, ketoacidosis, cardiovascular event, renal or acute infection were not included in the study. Patients were not allowed to take non-insulin pharmacotherapies or any other concomitant medicine throughout the study period.
All the subjects randomized were non-camel milk drinker. A written informed consent was obtained from the patients and in case of minors, from their parents. This study was a randomized, open clinical, parallel design single-center study.
Blood sugar level was measured twice a week before breakfast and before dinner, and insulin doses were titrated weekly according to mean blood sugar levels. Patients were instructed to inform immediately for any untoward event like hypo- or hyperglycemia and other complications. All patients were trained and provided with a one-touch profile memory glucometer Lifescan, Milpitas, CA, USA , along with strips for self-monitoring of blood glucose concentrations, and were instructed to record the glucose readings and insulin doses.
Vital signs, body weight, hematological and laboratory parameters, hemoglobin A1c HbA1c levels were monitored throughout the study. Patients were also monitored for symptoms of hypoglycemia, and glucose readings were obtained when hypoglycemic symptoms occurred. Anti-insulin antibodies detection, brucellosis agglutination test and enzyme-linked immunosorbent assay for tuberculosis were carried out annually.
Safety evaluations included detail physical examinations including vital signs and laboratory parameters. Blood sugar concentration was measured using the glucose oxidase method Trinder, ; Kaplan, Anti-insulin antibodies were estimated by radioimmunoassay Desbuquois and Aurbach, Statistical analysis was carried out by using the SPSS version Ltd, Bangalore, India.
The baseline difference between the two groups was analyzed using t -test for independent samples assuming heteroscedastic variance. Changes from baseline to end point were analyzed using analysis of variance. The groups were taken as independent variables. Insulin dose, mean blood sugar and HbA1c were taken as dependent variables and analyzed independently. The mean age observed in Group I and II was Male to female ratio in Group I and II was and , respectively.
The baseline characteristics of the study groups were similar in terms of BMI, fasting blood glucose, HbA1c, dose of insulin, plasma insulin, C-peptide and anti-insulin antibody Table 1. After 2 years of study, improvement in BMI was observed in both the groups, which may be attributed to adolescent growth along with good glycemic control Table 1.
Decrease in mean fasting blood glucose levels was observed in Group II, with a significant reduction in the doses of insulin requirement Table 1 , Figure 1 , whereas in Group I there was significant increase in insulin requirement. In three diabetic patients of Group II, insulin requirement reduced to zero in the later phase of study.
Improvement in HbA1c levels was found more pronounced in Group II as compared with the control group. There was significant change in C-peptide levels in both the groups, as all the patients were on insulin therapy, whereas no change was observed in plasma insulin and anti-insulin antibodies Table 1. No significant treatment-emergent adverse events were reported in either group. Acceptability to camel milk was assessed by the occurrence of hypoglycemic and untoward event. No significant hypoglycemic event as well as untoward event was observed in the group receiving camel milk, thus, showing good acceptability of camel milk.
The goal of oral insulin therapy is to mimic the effects of pancreas-secreted insulin in order to control postprandial hyperglycemia and to prevent hypoglycemia between meals.
In previous separate clinical trials for 3 months, 6 months and 1 year, the efficacy of camel milk causing significant hypoglycemic effect was reported when given as adjunctive therapy. The present study demonstrated that there was statistically significant improvement in mean BMI in both the groups.
In this study, all the subjects were receiving insulin, conferring in better glycemic control, which in turn improved the mean BMI.
The important observation of the present study was a significant reduction in insulin requirement Among the 12 subjects in camel milk-consuming group, each patient had significant response to reduction in insulin requirement, but the remarkable observation was gradual reduction upto zero in three subjects. Two out of these three subjects maintained this zero level continuously, from 18th to 21st month, till the end of study.
Exact reason behind reduction in insulin requirement upto zero in these three subjects is not known. Researchers, exploring the field of non-invasive insulin delivery, have been continuously making efforts to administer insulin through different systems including oral delivery.
The insulin-requirement-lowering effect due to camel milk supplementation in this study suggests emergence of camel milk as a new oral insulin, which can give new dimensions to the therapeutic insulin era. This may be strongly recommended, as insulin requirement reduced to zero in three diabetic subjects.
The lack of hypoglycemic events in this study is encouraging and it looks more acceptable for patients with type 1 diabetes. The promising data in this study are in consistent with study conducted by Clement et al. The significant reduction was observed in HbA1c levels in camel-milk receiving group 7.
HbA1c is marker of glycemic control and improvement in its values clearly indicates better glycemic control. Fasting plasma insulin levels did not reveal any significant change in each group, though significant increase in C-peptide levels in camel milk group 0. In our previous study, after 1 year of camel milk supplementation, the C-peptide level increased from 0. Fasting insulin per se cannot be considered as an accurate surrogate for insulin sensitivity. It can simply be reported as a quantitative reflection of insulin resistance.
Several studies have shown that patients treated with insulin, develop significant insulin antibodies after some period and these subjects occasionally experience prolongation of insulin action, which produces nocturnal hypoglycemia and insulin resistance during the day period Jeandidier et al. In the present study, we did not observe marked changes in the positive proportion of insulin antibodies level.
The exact cause of hypoglycemic effect of camel milk is not known. Agamy et al. The lack of coagulum formation of camel milk may also be helpful in taking the insulin present in it unchanged to intestine where it can be absorbed even if some amount is destroyed in the passage.
Beg et al. Anecdotal reports also suggested that camel milk consumption is associated with low prevalence of diabetes. In an epidemiological observation, Agrawal et al. They reported a very low prevalence of both variables, which may be due to the protective influence of camel milk. The results of the present study are in agreement with the previous observation of positive effects of supplementation of camel milk as an adjunctive to insulin therapy in type 1 diabetic patients Agrawal et al.
Despite the limited size of the study population, we were able to demonstrate a significant association between camel milk consumption and gradual reduction in insulin requirement in type 1 diabetic subjects. Further studies are needed to verify these observations. In conclusion, the results of the present study throw a light on the potential use of camel milk as an adjunct to insulin therapy, for better glycemic control and good quality of life.
Studies on the production of ice cream from camel milk products. Aust J Dairy Technol 44 , 31— Google Scholar. Antibacterial and antiviral activity of camel milk protective proteins.
EFFECT OF RAW CAMEL MILK IN TYPE 1 DIABETIC PATIENTS : 1 YEAR RANDOMISED STUDY
Abdel-Reheim 1 , Wessam W Addaleel 1. All Rights Reserved. The present study aimed to assess the hypoglycaemic effects of camel milk CM and its efficiency on dyslipidaemia and altered antioxidant defence system in streptozotocin diabetic albino rats. The animals were divided into 2 categories; the pre-treated and the treated groups. Article Outline 1.
Camel milk for reduction of diabetes risk: Are we heading toward the right direction? Correspondence Address : Dr. Air Force Head Quarters, Nr. Diabetes is emerging as an important public health problem in India imparting huge burden on healthcare economics. Recently a milk packaging company has introduced camel milk product with its potential use in reducing risk of diabetes. In this study, we had evaluated the available evidences and found that though camel milk may have some benefits for the patients with type 1 diabetes, its efficacy for improving glycemic profile of type 2 diabetes is highly controversial and further evidences in the form of randomized controlled trials are needed to substantiate the effect.
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Agrawal and R. Beniwal and S. Sharma and D.
The main treatment of type 1 diabetes mellitus (DM) is insulin replacement via parenteral routes, which is far from satisfactory. Camel milk is an alternative to.
Can Camel Milk Help Your Diabetes? What You Should Know
For centuries, camel milk has been an important source of nutrition for nomadic cultures in harsh environments like deserts. We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission.
Controlling diabetes, a worldwide metabolic disease, by effective alternative treatments is currently a topic of great interest. Camel milk is believed to be a suitable hypoglycemic agent in experimental animals and patients with diabetes. The current systematic review aimed at evaluating the effect of camel milk on diabetes. A comprehensive search was dine in PubMed and Scopus for all clinical trials and animal studies documented up to , which focused on the effect of camel milk on diabetes markers. Studies which assessed the effects of camel milk, with no dose limit, on glucose parameters and lipid profiles in animals or humans with diabetes, were included.
Camel milk has many health benefits, but did you know that it may also be effective for managing type 1 diabetes? Insulin is an important substance for getting glucose to the cells of the body. These people are usually young adults and children.
Diabetes mellitus alters oxidative stability and immune response.